To get to Santa Cruz from Santiago, you can take a bus from the Alameda Bus Terminal or from the Pajaritos Terminal, both located in downtown Santiago. The trip lasts approximately 3 and a half hours.
You can also drive, taking Ruta 5 Sur south for approximately 180 km, and then take Ruta 90 west for another 25 km until you reach Santa Cruz.
If you are on the coast, you can take a bus from the city of Pichilemu, which is approximately 60 km west of Santa Cruz, and the trip takes around 2 hours.
You can also drive through Route I-90 to the east from Pichilemu, which will take about 1 hour.
See more about how to get to Santa Cruz
See also information on Pichilemu.